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Image Search Results
Journal: Nature Communications
Article Title: Late-stage (radio)fluorination of alkyl phosphonates via electrophilic activation
doi: 10.1038/s41467-024-54208-y
Figure Lengend Snippet: a Late-stage radiofluorination of PET tracers and 18 F-synthons. RCC TLC determined by radio-TLC ( n = 3); RCY = isolated 18 F-product activity amount/starting amount of radioactivity (decay corrected). cLog P values were predicted using ALOGPS 2.1 ( http://www.vcclab.org/lab/alogps ). Blue arrows pointing upward indicate an increase in cLog P /Log D 7.4 compared to the parent compound, while downward arrows indicate a decrease. The small pink ball after cLog P /Log D 7.4 represents the target of the parent compound. b Preparation α v β 3 integrin receptor developer [ 18 F]BFPA-E[c(RGDyK)] 2 . c MicroPET images of [ 18 F]BFPA-E[c(RGDyK)] 2 in U87MG xenograft mice at 30 min after tail vein injection. 200 μg of E[c(RGDyK)] 2 was used to block the tumor uptake of [ 18 F]BFPA-E[c(RGDyK)] 2 . The white circle is the tumor area. d Preparation of PET tracer [ 18 F]BFPA-Flurpiridaz targeting MC I. e MicroPET/CT images of healthy mice [ 18 F]BFPA-Flurpiridaz 60 min after caudal vein injection. f Molecular Docking. Flurpiridaz and BFPA-Flurpiridaz to MC I (PDB: 7ZM8). Cyan: residues composing the substrate-binding cavity; yellow: residues forming hydrogen bonds; yellow dashed lines: locations of hydrogen bond.
Article Snippet: The
Techniques: Isolation, Activity Assay, Radioactivity, Injection, Blocking Assay, Binding Assay